In 1995, Dr. Bruce Beutler was an Associate Professor of Internal Medicine at UT Southwestern and a Howard Hughes Medical Institute Investigator. He and some UT Southwestern colleagues developed a tumor necrosis factor (TNF) inhibitor molecule. The molecule was the basis for new rheumatoid arthritis drugs being tested at the time by a number of pharmaceutical companies. He would later go on to share one-half of the Nobel Prize in Physiology or Medicine (2011) with Jules A. Hoffman for their discovery of receptor proteins that recognize disease-causing agents and activate innate immunity. Dr. Beutler was elected to the National Academy of Sciences and to the National Academy of Medicine in 2008.
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