In general, when a virus enters the body, it binds to receptors on a cell's surface. Once the virus and the cell membrane fuse, the genetic material from the virus can enter the cell and begin to replicate, infecting the body and triggering the immune system to fight off the virus. But coronaviruses, including SARS-CoV-2 that causes COVID-19, can evade detection by the cells they infect. In this lecture, Vincent Tagliabracci, Ph.D., discusses research his lab conducted that revealed how coronaviruses evade detection. Understanding how this disguise works could lead to potential new treatment targets for coronaviruses.