Dr. Daniel W. Foster and Dr. John McGarry collaborated on studies of metabolism in the 1980s. They looked at how catabolic metabolism processes were controlled, focusing their research on how the liver is 'converted' into an organ that makes ketone bodies. Their critical discovery was that malonyl-coenzyme A blocks fatty oxidation and ketone body formation by inhibiting the enzyme carnitine palmitoyl transferase I (CPTI). As a result of this work, Dr. Foster received the Banting Medal from the American Diabetes Association in 1984.
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